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アフリカツメガエル胚右側板中胚葉におけるNodalシグナリングの活性化は内臓左右軸を逆転する(2003-2004年度神奈川大学共同研究奨励助成論文)
http://hdl.handle.net/10487/1426
http://hdl.handle.net/10487/1426d1fed6ee-5c00-4ea2-ab79-7aacb4b96ea7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
SJKU Vol 16 2005 35-44.pdf (759.1 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-02-23 | |||||
| タイトル | ||||||
| タイトル | アフリカツメガエル胚右側板中胚葉におけるNodalシグナリングの活性化は内臓左右軸を逆転する(2003-2004年度神奈川大学共同研究奨励助成論文) | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Xenopus laevis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | left-right asymmetry | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | neurula | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Xnr-1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | pitx2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | microinjection | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
豊泉, 龍児
× 豊泉, 龍児× Toyoizumi, Ryuji× 茂木, 和枝× Mogi, Kazue× 日野, 晶也× Hino, Akiya× 小笠原, 強× Ogasawara, Tsuyoshi× 竹内, 重夫× Takeuchi, Shigeo |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In Xenopus, multiple nodal-related genes are expressed during early embryogenesis. Among them, only Xenopus nodal related-1(Xnr-1) is expressed unilaterally in the left lateral plate mesoderm(LPM) at the late neurula-early tailbud stage. Early studies report that ectopic administration of Xnr-1 in the right hemisphere at the cleavage stage alters the left-right specification of the heart and visceral organs, or else makes a secondary axis. However, because Xnr-1 and other Xnrs function already at the blastula-gastrula stage, it is very difficult to evaluate the correct timing of the effects of excessively administered Xnr-1 from such a method. To elucidate the essential role of Xnr-1 within the left LPM, ectopic potentiation of Nodal signaling in the right lateral plate mesoderm was performed. Right-side injection of Nodal protein changed the laterality of Xnr-1 and Xenopuspitx2, but lefty, and fully (more than 90%) reversed the situs of the internal organs. Polyethyleneimine-based gene transfer of Xnr-1 mRNA in the right LPM also changed the laterality of pitx2 and fully (more than 90%) reversed the situs of the internal organs. Taken together, the potentiation of Xnr-1 signaling in the right LPM induces pitx2 in the right side and fully inverts the left-right axis of the heart and visceral organs, suggesting that the right LPM can transduce Nodal signaling, and only the absence of the Xnr-1 ligand silences the Nodal signaling in the right LPM. Normal left-right balance of Xnr-1 signaling is needed for the normal left-right specification of the internal organs. | |||||
| 書誌情報 |
Science Journal of Kanagawa University 巻 16, p. 35-44, 発行日 2005-05-25 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1880-0483 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA12068302 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| その他の言語のタイトル | ||||||
| その他のタイトル | The potentiation of Nodal signaling in the right lateral plate mesoderm inverts the left-right specification of the internal organs. | |||||
| 出版者 | ||||||
| 出版者 | 神奈川大学 | |||||
