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胎生ラット下垂体原基におけるレチノアルデヒド脱水素酵素の発現
http://hdl.handle.net/10487/00018159
http://hdl.handle.net/10487/0001815985454274-8884-4cfe-9082-eeb42fa6d75c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
13 胎生ラット下垂体原基におけるレチノアルデヒド脱水素酵素の発現 (1.8 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-09-21 | |||||
| タイトル | ||||||
| タイトル | 胎生ラット下垂体原基におけるレチノアルデヒド脱水素酵素の発現 | |||||
| 言語 | ja | |||||
| タイトル | ||||||
| タイトル | Expression of Retinaldehyde Dehydrogenase in the Pituitary Primordium of Rats | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | retinoic acid | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | retinaldehyde dehydrogenase | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Prop1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Pit-1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | embryo | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | rat | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | retinoic acid | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | retinaldehyde dehydrogenase | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Prop1 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Pit-1 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | embryo | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | rat | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
藤原, 研
× 藤原, 研× 藤原, 葉子× 堀口, 幸太郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Retinoic acid (RA) is a lipid-soluble bioactive substance, which is not only an essential factor in organogenesis, but is also involved in the regulation of cell functions in adult tissues. RA is synthesized from retinoids through oxidation processes, in which the retinaldehyde dehydrogenase (RALDH) family converts from retinal to RA. We previously reported that RALDH2 and RALDH3 were expressed in the developing anterior pituitary gland of rats. However, these RALDH-expressing cells have not been characterized. The present study aimed to clarify the spatiotemporal relationship between mRNA expressions of RALDHs and pituitaryspecific transcription factors (Prop1 and Pit-1) in the pituitary primordium of rat embryos. By in situ hybridization using digoxigenin-labeled cRNA probes, we successfully detected mRNA expressions for RALDH2, RALDH3, Prop1, and Pit-1. The results showed that RALDH2 and RALDH3 were expressed specifically in Rathke’s pouch on embryonic day 11.5 (e11.5), and were subsequently distributed in the pituitary primordium. On the other hand, the expression of Prop1 was observed from e12.5, and then was decreased after e15.5. Pit-1 mRNA was first detected on e15.5, and became distributed throughout the entire pituitary primordium during development. Moreover, Pit-1-positive cells expressed RALDH2 and RALDH3 in the pituitary primordium on e17.5. These results suggest that stem/progenitor cells of the anterior pituitary gland express RALDH2 and RALDH3. RA may act in an autocrine and/or paracrine manner to induce hormone-producing cells in the pituitary. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 原著 2021年度神奈川大学総合理学研究所共同研究助成論文 |
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| 書誌情報 |
en : Science Journal of Kanagawa University 巻 33, p. 95-102, 発行日 2022-07-30 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1880-0483 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA12068302 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | 神奈川大学総合理学研究所 | |||||
| 出版者 | ||||||
| 出版者 | Research Institute for Integrated Science, Kanagawa University | |||||
