{"created":"2023-05-15T11:52:42.887358+00:00","id":15094,"links":{},"metadata":{"_buckets":{"deposit":"f6634f10-0b40-492d-949f-8867389fb551"},"_deposit":{"created_by":10,"id":"15094","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"15094"},"status":"published"},"_oai":{"id":"oai:kanagawa-u.repo.nii.ac.jp:00015094","sets":["376:377:378:1428"]},"author_link":["37148","37205","37206","37148","37203","37204"],"item_3_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-07-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"102","bibliographicPageStart":"95","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"Science Journal of Kanagawa University","bibliographic_titleLang":"en"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Retinoic acid (RA) is a lipid-soluble bioactive substance, which is not only an essential factor in organogenesis, but is also involved in the regulation of cell functions in adult tissues. RA is synthesized from retinoids through oxidation processes, in which the retinaldehyde dehydrogenase (RALDH) family converts from retinal to RA. We previously reported that RALDH2 and RALDH3 were expressed in the developing anterior pituitary gland of rats. However, these RALDH-expressing cells have not been characterized. The present study aimed to clarify the spatiotemporal relationship between mRNA expressions of RALDHs and pituitaryspecific transcription factors (Prop1 and Pit-1) in the pituitary primordium of rat embryos. By in situ hybridization using digoxigenin-labeled cRNA probes, we successfully detected mRNA expressions for RALDH2, RALDH3, Prop1, and Pit-1. The results showed that RALDH2 and RALDH3 were expressed specifically in Rathke’s pouch on embryonic day 11.5 (e11.5), and were subsequently distributed in the pituitary primordium. On the other hand, the expression of Prop1 was observed from e12.5, and then was decreased after e15.5. Pit-1 mRNA was first detected on e15.5, and became distributed throughout the entire pituitary primordium during development. Moreover, Pit-1-positive cells expressed RALDH2 and RALDH3 in the pituitary primordium on e17.5. These results suggest that stem/progenitor cells of the anterior pituitary gland express RALDH2 and RALDH3. RA may act in an autocrine and/or paracrine manner to induce hormone-producing cells in the pituitary.","subitem_description_type":"Abstract"}]},"item_3_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"原著\n2021年度神奈川大学総合理学研究所共同研究助成論文","subitem_description_type":"Other"}]},"item_3_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"神奈川大学総合理学研究所"},{"subitem_publisher":"Research Institute for Integrated Science, Kanagawa University"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12068302","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1880-0483","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤原, 研"}],"nameIdentifiers":[{"nameIdentifier":"37148","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"37148","nameIdentifierScheme":"ローカル著者ID","nameIdentifierURI":" "}]},{"creatorNames":[{"creatorName":"藤原, 葉子"}],"nameIdentifiers":[{"nameIdentifier":"37203","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"堀口, 幸太郎"}],"nameIdentifiers":[{"nameIdentifier":"37204","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-09-21"}],"displaytype":"detail","filename":"13 胎生ラット下垂体原基におけるレチノアルデヒド脱水素酵素の発現.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"13 胎生ラット下垂体原基におけるレチノアルデヒド脱水素酵素の発現","url":"https://kanagawa-u.repo.nii.ac.jp/record/15094/files/13 胎生ラット下垂体原基におけるレチノアルデヒド脱水素酵素の発現.pdf"},"version_id":"00663c6c-3563-4199-9b43-751d7488832d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"retinoic acid","subitem_subject_scheme":"Other"},{"subitem_subject":"retinaldehyde dehydrogenase","subitem_subject_scheme":"Other"},{"subitem_subject":"Prop1","subitem_subject_scheme":"Other"},{"subitem_subject":"Pit-1","subitem_subject_scheme":"Other"},{"subitem_subject":"embryo","subitem_subject_scheme":"Other"},{"subitem_subject":"rat","subitem_subject_scheme":"Other"},{"subitem_subject":"retinoic acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"retinaldehyde dehydrogenase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Prop1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Pit-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"embryo","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"rat","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"胎生ラット下垂体原基におけるレチノアルデヒド脱水素酵素の発現","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胎生ラット下垂体原基におけるレチノアルデヒド脱水素酵素の発現","subitem_title_language":"ja"},{"subitem_title":"Expression of Retinaldehyde Dehydrogenase in the Pituitary Primordium of Rats","subitem_title_language":"en"}]},"item_type_id":"3","owner":"10","path":["1428"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-09-21"},"publish_date":"2022-09-21","publish_status":"0","recid":"15094","relation_version_is_last":true,"title":["胎生ラット下垂体原基におけるレチノアルデヒド脱水素酵素の発現"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-06-19T02:11:51.523903+00:00"}