| Item type |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2023-09-20 |
| タイトル |
|
|
タイトル |
性機能を調節する脊髄射精発生器ニューロンの脳への投射 |
|
言語 |
ja |
| タイトル |
|
|
タイトル |
Projection of Spinal Ejaculation Generator Neurons to the Brain |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
lumbar-spinothalamic |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
gastrin-releasing peptide |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
oxytocin receptor |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
spinal cord |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
male sexual function |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| ID登録 |
|
|
ID登録 |
10.24792/0002000108 |
|
ID登録タイプ |
JaLC |
| 著者 |
越智, 拓海
篠崎, 和歌子
石割, 隆輔
立石, 沙也加
坂本, 浩隆
小谷, 享
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
A spinal ejaculation generator (SEG) exists in the X layer of the rat spinal cord (lumbar spinal cord) at the L3-L4 level. SEG neurons express gastrin-releasing peptide (GRP) and oxytocin receptor (OXTR). We have previously reported that sexual experience sowe induced th expressions of GRP and OXTR in SEG neurons with. While SEG neurons project to the thalamic region and are thought to signal the completion of sexual behavior to the brain, it is still unclear where SEG neurons project to in the brain. The purpose of this study was to clarify the projection area of SEG neurons in the brain. Firstly, we analyzed the localizations of GRP-positive fibers in the brains of sexually experienced and naive male rats. GRP-positive fibers were observed in the parafascicular nucleus (PF), subparafascicular nucleus (SPF), and medial amygdala nucleus, posterodorsal part (MePD). In all cases, more GRP fibers were observed in sexually experienced males than in naive males. Secondly, we specifically lesioned SEG neurons using OXTR human diphtheria toxin receptor (Dtxr)-2A-channelhodopsin-2-(ChR2)-EYFP transgenic rats. The number of SEG neurons was reduced by half compared with controls. GRP- and YFP-positive fibers in the MePD were significantly reduced in rats with a loss of SEG neurons compared with controls. No differences were found in other brain regions, suggesting that SEG neurons project to the MePD and that sexual experience enhances input from the SEG neurons to the MePD. In addition, sexual experience might increase the GRP expression not only in the SEG neurons but also in GRP neurons of the brain. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
原著 2022年度神奈川大学総合理学研究所共同研究助成論文 |
|
言語 |
ja |
| 書誌情報 |
Science Journal of Kanagawa University
en : Science Journal of Kanagawa University
巻 34,
p. 49-53,
発行日 2023-07-30
|
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1880-0483 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12068302 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 出版者 |
|
|
出版者 |
神奈川大学総合理学研究所 |
|
言語 |
ja |
| 出版者 |
|
|
出版者 |
Research Institute for Integrated Science, Kanagawa University |
|
言語 |
en |
08 性機能を調節する脊髄射精発生器ニューロンの脳への投射.pdf (1.8 MB)
