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相模湾のクダウミヒドラ Tubularia sp. から単離した免疫抑制活性ステロールの構造と活性
http://hdl.handle.net/10487/1186
http://hdl.handle.net/10487/11864725bbd7-9ecb-42b5-af3c-37faaafa1ea8
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
kana-1-2-0006.pdf (2.1 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2009-02-23 | |||||
| タイトル | ||||||
| タイトル | 相模湾のクダウミヒドラ Tubularia sp. から単離した免疫抑制活性ステロールの構造と活性 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
釜野, 徳明
× 釜野, 徳明× Kamano, Yoshiaki× 五味, 和枝× Gomi, Kazue× 張, 恵平× Zhang, Hui-ping× 小竹, 文乃× Kotake, Ayano× 日野, 晶也× Hino, Akiya× 木津, 治久× Kizu, Haruhisa× 西川, 輝昭× Nishikawa, Teruaki× 薗部, 徹× Sonobe, Thoru× 大村, 武雄× Ohmura, Takeo |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Two immunosuppressive sterols, cholesta-5,23E-diene-3β, 25-diol (trans-liagosterol) (A) and cholesta-5,25 (26)-diene-3β, 24ζ-diol (B) were isolated respectively from the Sagami Gulf Hydrozoa Tubularia sp. by the guide of Mitogen bioassey. Structural determination was accomplished mainly by utilizing high-field (400MHz) 2D-NMR experiments, comparing to the spectra of cholesterol. Although these sterols, A and B, were known as the minor components of marine red alga, the presence in marine animal Hydrozoa such as Tubularia sp. was a new discovery. Sterol A inhibited T lymphocyte proliferation which was induced by plant lectins, concanavalin A (Con-A) and phytochemagglutinin (PHA), more than B lymphocyte proliferation which was induced by lipopolysaccharide (LPS). The activity of sterol B was more week than that of sterol A. On the other hand, by the Mitogen bioassay with hydrocortisone (HC) as a standard inhibitor and related five steroids, β-sitosterol (C), stigmesterol acetate (D), resibufogenin (E), 14,21-epoxy-3 β-hydroxy-5 β-chola-20 (21), 22-dienoic acid (F) and ergosterol (G), the inhibition of sterol A for PHA response was found to be most strong in them. However, for LPS response, the inhibition of hydrocortisone (HC) was more powerful than that of sterol A. Also, the immunosuppresive activity of related steroids, C, D, E and G was little found. | |||||
| 書誌情報 |
年報 巻 '95, p. 11-20, 発行日 1996-03 |
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| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11822302 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| その他の言語のタイトル | ||||||
| その他のタイトル | Structure and Immunosuppresive Activity of Sterols isolated from The Sagami Gulf Hydrozoa Tubularia sp. | |||||
| 出版者 | ||||||
| 出版者 | 神奈川大学 | |||||
