{"created":"2023-05-15T11:46:25.424842+00:00","id":6961,"links":{},"metadata":{"_buckets":{"deposit":"1379d730-6094-473a-ab91-8c76a1c7f8f2"},"_deposit":{"created_by":1,"id":"6961","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"6961"},"status":"published"},"_oai":{"id":"oai:kanagawa-u.repo.nii.ac.jp:00006961","sets":["376:377:378:558"]},"author_link":["20944","20942","20945","20941","20943","20939","20940","20938"],"item_3_alternative_title_20":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Screening for an Efficient Procedure to Generate Non-Congenital Albino Zebrafish using Chemical Compounds or Antisense Oligonucleotides"}]},"item_3_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-06-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"38","bibliographicPageStart":"33","bibliographicVolumeNumber":"19","bibliographic_titles":[{"bibliographic_title":"Science Journal of Kanagawa University"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Zebrafish is a good model organism for developmental biology and biomedical\nresearch. In its early developmental stages, zebrafish is very transparent, and the speed of\ndevelopment is rapid, however, its larva is highly pigmented, and thus it is almost\nimpossible to observe the internal organs using non-invasive methods. Here we report the\neffects of antisense morpholino oligonucleotides (MO) and organic compounds which target\nzebrafish melanogenesis. Antisense MO for zebrafish tyrosinase and phenyl-thiourea\n(PTU) are highly effective to reduce the pigmentation of melanosomes in melanophores.\nArbutin and Kojic acid are partially effective, and Fullerene C60 is not effective for\ninhibiting zebrafish melanogenesis. Except for pigmentation, all these reagents did not\ndisrupt normal embryogenesis and the left-right specification of the heart. After 8-day\ntreatment with PTU, we succeeded in visualizing the shape of the brain ventricle by\ninjecting with Qdot 655 (red nanocrystal). The inhibition of melanogenesis is useful for the\nstudy of brain development using zebrafish larvae.","subitem_description_type":"Abstract"}]},"item_3_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"■原 著■ 2007 年度神奈川大学総合理学研究所共同研究助成論文","subitem_description_type":"Other"}]},"item_3_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"神奈川大学"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12068302","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1880-0483","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"茂木, 和枝"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mogi, Kazue"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"永井, 敦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagai, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"日野, 晶也"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hino, Akiya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"豊泉, 龍児"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Toyoizumi, Ryuji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-11-20"}],"displaytype":"detail","filename":"07 19 33-38.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"07 19 33-38.pdf","url":"https://kanagawa-u.repo.nii.ac.jp/record/6961/files/07 19 33-38.pdf"},"version_id":"d0a7c770-bdc9-49bf-8770-f66efe8b3e80"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"薬剤処理やアンチセンス核酸注射によるゼブラフィッシュの後天的アルビノ個体の作製方法の探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"薬剤処理やアンチセンス核酸注射によるゼブラフィッシュの後天的アルビノ個体の作製方法の探索"}]},"item_type_id":"3","owner":"1","path":["558"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-12-21"},"publish_date":"2009-12-21","publish_status":"0","recid":"6961","relation_version_is_last":true,"title":["薬剤処理やアンチセンス核酸注射によるゼブラフィッシュの後天的アルビノ個体の作製方法の探索"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T15:44:41.773680+00:00"}