@article{oai:kanagawa-u.repo.nii.ac.jp:00006928, author = {Matsumoto, Masakatsu and 松本, 正勝 and Watanabe, Nobuko and 渡辺, 信子 and Ohashi, Mamoru and 大橋, 守 and Fujimori, Ken and 藤森, 憲}, journal = {Science Journal of Kanagawa University}, month = {May}, note = {The chemiluminescent efficiency of hydroxyphenyl-substituted dioxetanes is well known to decrease significantly in an aqueous medium, though more than bioluminescence in an aprotic medium. We investigated here the effect of hydrogen bonding on singlet-chemiexcitation and fluorescence efficiency of the emitter produced for charge-transfer-induced chemiluminescence by the use of dioxetanes bearing a 3-hydroxyphenyl moiety substituted with a proton-donating group at the 4-position as a model substrate. Based on this investigation, four bicyclic dioxetanes bearing a 4-(benzoazol-2-yl)-3-hydroxyphenyl moiety were designed and synthesized. The thus-realized dioxetanes exhibited chemiluminescence with markedly high efficiency in aqueous medium as well as in aprotic medium.}, pages = {83--84}, title = {Design and Synthesis of Dioxetane-Based Chemiluminescent Substrates with High Efficiency in Aqueous System(By a grant Research Institute for Integrated Science, Kanagawa University)}, volume = {17}, year = {2006} }