{"created":"2023-09-14T05:18:28.155953+00:00","id":2000097,"links":{},"metadata":{"_buckets":{"deposit":"e3ccffd9-3db9-4965-86ea-872cda3b165c"},"_deposit":{"created_by":10,"id":"2000097","owner":"10","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"2000097"},"status":"published"},"_oai":{"id":"oai:kanagawa-u.repo.nii.ac.jp:02000097","sets":["376:377:378:1694564780134"]},"author_link":["34316","34316"],"item_3_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-07-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"43","bibliographicPageStart":"31","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"Science Journal of Kanagawa University"},{"bibliographic_title":"Science Journal of Kanagawa University","bibliographic_titleLang":"en"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Developing external gill of the urodelan larva is a good model for the study of the organogenesis of vertebrate respiratory organ. We can observe the entire process of the branching morphogenesis of the newt external gills non-invasively, so the newt gills are amenable to experimental manipulations and/or pharmacological treatments. In this study we examined the role of sonic hedgehog signaling for the external gill branching morphogenesis using an emerging model organism, Iberian ribbed newt (Pleurodeles waltl ). We found that administration of the sonic hedgehog inhibitor SANT-1 markedly reduced the number of fine gill filaments (fimbriae), and the direction of the protrusion of the gill stems (rachises) shifted toward the anterior more than the intact ones, resulting in the radial expansion of the three pairs of the gill stems. Immunohistochemistry targeting the striated muscles revealed that the fasciculation of the gill muscles in the posterior portion within the gill stems in normal larvae was impaired after the administration of the sonic hedgehog inhibitor. Based on these results, we propose that gill primordia develop to protrude the fine gill filaments in their posterior portions in reference to the sonic hedgehog signaling-dependent antero-posterior polarity within developing gills.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_3_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24792/0002000097","subitem_identifier_reg_type":"JaLC"}]},"item_3_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"神奈川大学総合理学研究所","subitem_publisher_language":"ja"},{"subitem_publisher":"Research Institute for Integrated Science, Kanagawa University","subitem_publisher_language":"en"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12068302","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1880-0483","subitem_source_identifier_type":"PISSN"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"桃井, 環","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"豊泉, 龍児","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"34316","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"34316","nameIdentifierScheme":"ローカル著者ID"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-09-14"}],"filename":"06 有尾目両生類イベリアトゲイモリの外鰓の形態形成におけるSonic hedgehogシグナル伝達経路の役割について.pdf","filesize":[{"value":"3.5 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kanagawa-u.repo.nii.ac.jp/record/2000097/files/06 有尾目両生類イベリアトゲイモリの外鰓の形態形成におけるSonic hedgehogシグナル伝達経路の役割について.pdf"},"version_id":"c25d38e0-6077-4ae9-ad4f-a9302392abc3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"newt","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"larva","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"external gill","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"branching morphogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sonic hedgehog","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"FGF","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"有尾目両生類イベリアトゲイモリの外鰓の形態形成におけるSonic hedgehogシグナル伝達経路の役割について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"有尾目両生類イベリアトゲイモリの外鰓の形態形成におけるSonic hedgehogシグナル伝達経路の役割について","subitem_title_language":"ja"},{"subitem_title":"Study on the Role of the Sonic hedgehog Signaling Pathway in the Morphogenesis of Urodelan External Gills","subitem_title_language":"en"}]},"item_type_id":"3","owner":"10","path":["1694564780134"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-09-14"},"publish_date":"2023-09-14","publish_status":"0","recid":"2000097","relation_version_is_last":true,"title":["有尾目両生類イベリアトゲイモリの外鰓の形態形成におけるSonic hedgehogシグナル伝達経路の役割について"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-10-11T00:15:23.025783+00:00"}