@article{oai:kanagawa-u.repo.nii.ac.jp:00014061,
 author = {加部, 義夫},
 journal = {Science Journal of Kanagawa University},
 month = {Jun},
 note = {Organic compounds containing carbon-metal bonds are called organometallic com-
pounds. Such compounds have been known and studied since the 19th century and have been widely used to modify synthetic transformation in modern organic chemistry. It is considered that many educational benefits could result in the use of reaction types and discovery episode for undergraduates and graduate classes in organic and organometallic chemistry. In 1968, Heck began to investigate reactions of phenyl mercury acetate with Li2[PdCl4] solution under an ethylene atomosphere to produce styrene. Due to the high toxicity of mercury, he changed to the direct coupling of aryl iodide with ethylene in the presence of a palladium catalyst, the so-called Heck reaction. In the 1940's, Kharasch investigated the Grignard reaction in the presence of catalytic amounts of salts of transition metals to produce homo and cross-coupling products with organic halides, considered to be produced by a radical mechanism. In 1970-72, several revolutionary findings by Yamamoto, Kochi, Corriu, Kumada, and Tamao odified this Griganrd reaction with Ag, Cu, Fe, and Ni catalysts, which is now available as a modern Pd catalyzed cross-coupling reaction that is synthetically powerful, devised by Negishi, Sonogashi-ra, Migita, Kosugi, Suzuki, Miyaura, and Hiyama. The mechanism of reaction was disclosed as oxidative addition and reductive elimination of low valent Pd(0) in the catalytic cycle., Departmental Bulletin Paper, 教育論文},
 pages = {97--105},
 title = {反応のタイプと発見のエピソードで学ぶ有機金属化学(9)},
 volume = {32},
 year = {2021}
}